ATP synthase membrane subunit c locus 3 (ATP5MC3) (ATP5MC3)

ATP5G3 mRNA encodes the ATP synthase membrane subunit c locus 3 (ATP5MC3), a vital component of the mitochondrial ATP synthase F0 complex (UniProt: P48201). This subunit forms the transmembrane c-ring that rotates in response to proton flow, providing the mechanical energy required for ATP synthesis (NCBI Gene: 518). In many cancers, such as breast and colorectal carcinoma, ATP5G3 is upregulated to facilitate the high bioenergetic demands of tumor progression and resistance to apoptosis (PubMed: 28651543). Experimental approaches using siRNA to knockdown ATP5G3 mRNA have demonstrated reduced mitochondrial membrane potential and inhibited cell growth, highlighting its potential as a therapeutic target (PubMed: 25670014). Furthermore, the accumulation of the subunit c protein is a hallmark of neuronal ceroid lipofuscinoses (NCL), suggesting that modulating its expression could have implications for neurodegenerative disease management (PubMed: 12117478). While small molecule inhibitors like oligomycin target the protein complex, antisense technologies specifically targeting the mRNA are being investigated to achieve isoform-specific modulation of mitochondrial function.

Other names

ATP5G3ATP synthase F0 complex subunit C3ATP synthase lipid-binding proteinP3ATPase subunit c

Inhibition of the F0 complex proton channel to prevent ATP synthesis and induce mitochondrial dysfunction.