ATP synthase membrane subunit f, mitochondrial (ATP5MF)

ATP synthase membrane subunit f, mitochondrial (ATP5MF) is a minor component of the mitochondrial ATP synthase complex, specifically part of the Fo domain, which forms the proton channel in the mitochondrial inner membrane. This enzyme complex is responsible for synthesizing ATP from ADP and inorganic phosphate using the energy stored in a transmembrane proton gradient established during oxidative phosphorylation. The ATP5MF subunit is essential for the normal function of the Fo domain and therefore for cellular energy metabolism. Genetic defects or altered regulation of ATP5MF are implicated in mitochondrial diseases and potentially in cancer and neurodegeneration[1][2][3][4][5][6][7].

Other names

ATP synthase F(0) complex subunit f, mitochondrialATP synthase F chain, mitochondrialF1Fo-ATPase synthase f subunitATP synthase f chain, mitochondrialF1Fo-ATP synthase complex Fo membrane domain f subunitATP5J2ATP5JLATP synthase, H+ transporting, mitochondrial F0 complex, subunit fATP synthase, H+ transporting, mitochondrial Fo complex subunit F2F1F0-type ATPase subunit f

Inhibition of ATP synthase proton channel (general, by drugs like oligomycin, likely targeting Fo complex, not specifically subunit f) ; Modulation of mitochondrial energy production (general, for ATP synthase inhibitors)