ATP synthase peripheral stalk subunit d, mitochondrial (ATP5PD)

ATP synthase peripheral stalk subunit d, mitochondrial (ATP5PD), is a protein subunit of the proton-transporting mitochondrial ATP synthase (Complex V, F1F0 ATP synthase), specifically a component of the peripheral stalk within the Fo complex. This protein plays a structural role in linking the catalytic F1 domain with the membrane-embedded Fo domain, supporting rotational catalysis required for the synthesis of ATP from ADP and inorganic phosphate during oxidative phosphorylation. ATP5PD is essential for normal mitochondrial energy production and is localized in the mitochondrial inner membrane[5][6][3][1].

Other names

ATP5HMy032ATPase subunit dATPQATP5JDATP synthase D chain, mitochondrialATP synthase subunit d, mitochondrialATP synthase, H+ transporting, mitochondrial F0 complex, subunit dATP synthase, H+ transporting, mitochondrial F1F0, subunit dATP synthase, H+ transporting, mitochondrial Fo complex subunit DATP synthase, H+ transporting, mitochondrial Fo complex, subunit dMy032 protein[3][4][5][6]

Not applicable (no approved drugs directly targeting ATP5PD; ATP synthase as a whole can be inhibited, e.g., by oligomycin, but this is not specific for subunit d)