ATPase H+ transporting accessory protein 1-like (ATP6AP1L)

ATPase H+ transporting accessory protein 1-like (ATP6AP1L) is a gene in humans denoted as a pseudogene, highly homologous to ATP6AP1, which encodes a functional accessory subunit of the vacuolar (H+)-ATPase (V-ATPase) proton pump[5][13]. In species where a protein is expressed (such as mouse and rat), ATP6AP1L acts as an accessory subunit required for luminal acidification of secretory vesicles and the assembly, stability, and targeting of V-ATPase complexes[3][7][8][11]. V-ATPases play a crucial role in acidifying intracellular organelles, regulating cellular pH, protein degradation, membrane trafficking, and autophagy[4][10]. The ATP6AP1L gene is predicted to enable ATPase activator activity and has been associated with the regulation of cellular pH, but in humans it does not encode a functional protein and is not implicated directly as a therapeutic target[5][13].

Other names

ATPase, H+ transporting, lysosomal accessory protein 1-likeV-type proton ATPase subunit S1-like proteinVacuolar proton pump subunit S1-like protein

None applicable for ATP6AP1L; in species where a functional protein is present, it is predicted to regulate assembly and function of V-type proton ATPase complexes, facilitating proton transport across membranes