Atrial Natriuretic Factor Receptor B (NPR-B)

Atrial Natriuretic Factor Receptor B Overview

Atrial natriuretic factor receptor B, also known as natriuretic peptide receptor B (NPR-B) or NPR2, is a transmembrane receptor that primarily binds C-type natriuretic peptide (CNP). It is part of the guanylyl cyclase-coupled family of natriuretic peptide receptors. Upon binding its ligand, NPR-B catalyzes the conversion of GTP to cyclic GMP (cGMP), acting as a membrane-bound guanylyl cyclase. cGMP serves as a second messenger mediating downstream effects such as activation of cGMP-dependent protein kinases and modulation of ion channels. NPR-B plays a role in vasodilation, inhibition of vascular smooth muscle cell proliferation, regulation of atrial electrophysiology, and skeletal growth. Mutations in *NPR2* are associated with certain forms of skeletal dysplasia and may contribute to essential hypertension.

Mechanism of Action

Binding of CNP leading to activation of guanylyl cyclase and increased cGMP production.

Biological Functions

Safety Considerations