Autophagosome-Lysosome Fusion Process ()

Autophagosome-Lysosome Fusion Process Overview

The autophagosome–lysosome fusion process is a critical step in macroautophagy, a conserved catabolic pathway in eukaryotic cells. During this process, cytoplasmic material is first sequestered into double-membrane vesicles called autophagosomes. These autophagosomes then fuse with lysosomes to form autolysosomes, where the cargo is degraded by lysosomal enzymes. This fusion event ensures the breakdown and recycling of cellular components, maintaining cellular homeostasis. Key molecular players include SNARE proteins (Stx17, SNAP29, VAMP8), Rab7, HOPS complex, ATG14, and INPP5E. Defects in this process are linked to various diseases, including neurodegenerative disorders and cancer.

Mechanism of Action

Inhibition of autophagosome-lysosome fusion

Biological Functions

Safety Considerations

Interacting Drugs