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Autophagosome-Lysosome Fusion Process
- Molecular classification
- Cellular process, Protein-protein interaction, Membrane fusion
01
Overview
The autophagosome–lysosome fusion process is a critical step in macroautophagy, a conserved catabolic pathway in eukaryotic cells. During this process, cytoplasmic material is first sequestered into double-membrane vesicles called autophagosomes. These autophagosomes then fuse with lysosomes to form autolysosomes, where the cargo is degraded by lysosomal enzymes. This fusion event ensures the breakdown and recycling of cellular components, maintaining cellular homeostasis. Key molecular players include SNARE proteins (Stx17, SNAP29, VAMP8), Rab7, HOPS complex, ATG14, and INPP5E. Defects in this process are linked to various diseases, including neurodegenerative disorders and cancer.
- Other names
- Autophagosome-lysosome fusionAutophagy completionAutolysosome formation
02
Mechanism of action
Inhibition of autophagosome-lysosome fusion
03
Biological functions
Degradation of cellular componentsRecycling of cellular componentsCellular homeostasisAutophagyImmune response regulation
04
Disease associations
Neurodegenerative disordersCancerInfectious diseasesInflammatory diseases
05
Safety considerations
Off-target effects of autophagy inhibitorsPotential disruption of cellular homeostasis
06
Interacting drugs
Pharmacological inhibitors of autophagy
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