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Target intelligence / Profile preview
Auxin Receptor (Plant) (TIR1/AFB)
- Target
- TIR1/AFB
- Molecular classification
- Receptor, F-box protein, E3 ubiquitin ligase component
01
Overview
The auxin receptor in plants, primarily the TIR1/AFB family of F-box proteins, is a key component of the SCF^TIR1/AFB E3 ubiquitin ligase complex. It perceives the plant hormone auxin (IAA), leading to the ubiquitination and degradation of Aux/IAA transcriptional repressors. This releases ARF transcription factors to regulate gene expression and control diverse aspects of plant growth and development.
- Other names
- TRANSPORT INHIBITOR RESPONSE 1TIR1AUXIN SIGNALING F-BOX proteinsAFBs
02
Mechanism of action
Auxin binding promotes degradation of Aux/IAA transcriptional repressors via SCF^TIR1/AFB E3 ubiquitin ligase complex-mediated ubiquitination and proteasomal degradation, leading to ARF transcription factor activation or repression of target gene expression.
03
Biological functions
Auxin perceptionSignal transductionTranscriptional regulationProtein degradationPlant growth and developmentEmbryogenesisOrganogenesisTropismsApical dominanceRoot/shoot growth
04
Disease associations
Not applicable to human disease, primarily plant biology
05
Safety considerations
Not applicable to human therapeutics; relevant to plant biotechnology and agricultural applications.
06
Interacting drugs
Indole-3-acetic acid (IAA)
2 more in the full profile.
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