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Target intelligence / Profile preview
AXL receptor tyrosine kinase (AXL)
- Target
- AXL
- Molecular classification
- Receptor tyrosine kinase (RTK), TAM family RTK
01
Overview
AXL is a receptor tyrosine kinase belonging to the TAM family. It plays crucial roles in cell proliferation, survival, migration, and differentiation, and is implicated in cancer progression, metastasis, and drug resistance. AXL activation leads to downstream signaling via PI3K-AKT-mTOR, MEK/ERK, NF-kB, and JAK/STAT pathways. It also functions in the immune system by inhibiting innate immunity and promoting efferocytosis. Dysregulation of AXL is frequently observed in various cancers, making it an attractive therapeutic target.
- Other names
- AnexelektoArkTyro7UFO
02
Mechanism of action
Inhibition of AXL kinase activity, blocking GAS6/AXL interaction, or targeting downstream signaling pathways (PI3K-AKT-mTOR, MEK/ERK, NF-kB, JAK/STAT).
03
Biological functions
Cell proliferationCell migrationCell differentiationCell survivalInnate immune inhibitionEfferocytosisVascular smooth muscle homeostasisAngiogenesisImmune modulation
04
Disease associations
CancerTriple-negative breast cancer (TNBC)Acute myeloid leukemia (AML)Non-small-cell lung cancer (NSCLC)Pancreatic cancerOvarian cancerDrug resistanceMetastasis
05
Safety considerations
Potential off-target effects of TKIsDevelopment of resistance mechanismsImmunosuppression
06
Interacting drugs
Small molecule inhibitors (TKIs) targeting AXL
2 more in the full profile.
07
Biomarkers
AXL expression levels in tumor tissueGAS6 levels
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