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Target intelligence / Profile preview
B cell antigen CD20 (CD20)
- Target
- CD20
- Molecular classification
- MS4A family, Transmembrane protein
01
Overview
CD20, also known as B cell antigen CD20, is a transmembrane protein expressed on the surface of B lymphocytes (B cells). It serves as a key biomarker and therapeutic target in various B-cell malignancies and autoimmune diseases. It plays a role in regulating calcium influx into B cells and maintains the resting state organization of receptors on mature human B lymphocytes. Anti-CD20 monoclonal antibodies are widely used to treat both malignant and some autoimmune conditions by depleting pathogenic B-cells. CD20 does not internalize upon antibody binding nor shed from the surface under normal conditions and is absent from stem/progenitor/plasma cells, minimizing off-target toxicity.
- Other names
- Cluster of Differentiation 20
02
Mechanism of action
Complement-dependent cytotoxicity (CDC), Antibody-dependent cellular cytotoxicity (ADCC), Direct induction of apoptosis
03
Biological functions
Calcium regulationB-cell receptor signalingRegulation of B lymphocyte resting stateSignal transductionImmune response
04
Disease associations
Chronic lymphocytic leukemia (CLL)Diffuse large B-cell lymphoma (DLBCL)Mantle cell lymphomaFollicular lymphomaAutoimmune diseasesCancer
05
Safety considerations
B-cell depletionInfusion reactionsIncreased risk of infection
06
Interacting drugs
Rituximab
07
Biomarkers
CD20 expression level
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