B cell antigen CD20 (CD20)

B cell antigen CD20 Overview

CD20, also known as B cell antigen CD20, is a transmembrane protein expressed on the surface of B lymphocytes (B cells). It serves as a key biomarker and therapeutic target in various B-cell malignancies and autoimmune diseases. It plays a role in regulating calcium influx into B cells and maintains the resting state organization of receptors on mature human B lymphocytes. Anti-CD20 monoclonal antibodies are widely used to treat both malignant and some autoimmune conditions by depleting pathogenic B-cells. CD20 does not internalize upon antibody binding nor shed from the surface under normal conditions and is absent from stem/progenitor/plasma cells, minimizing off-target toxicity.

Mechanism of Action

Complement-dependent cytotoxicity (CDC), Antibody-dependent cellular cytotoxicity (ADCC), Direct induction of apoptosis

Biological Functions

Safety Considerations

Interacting Drugs

Associated Biomarkers