Gosset Molecular Classification
Signaling pathway, Immune signaling pathway
Other Names
B cell receptor pathway, BCR pathway
Disease Roles
B-cell Receptor Signaling Pathway Overview
The B-cell receptor (BCR) signaling pathway is fundamental to the development, activation, and function of B lymphocytes. The pathway is initiated when the membrane immunoglobulin (mIg) component of the BCR binds a specific antigen. This event triggers a cascade of intracellular signaling events that regulate key processes such as cell survival, proliferation, differentiation into plasma cells or memory B cells, and maintenance of immune tolerance.
Mechanism of Action
Inhibition of proximal kinases in the BCR signaling cascade, leading to reduced downstream signaling and tumor cell death.
Biological Functions
Signal transduction
B cell activation
Cell survival
Cell proliferation
Cell differentiation
Immune response
Tolerance
Apoptosis
Disease Associations
Autoimmunity
Lymphoma
Chronic Lymphocytic Leukemia (CLL)
Safety Considerations
- Off-target effects of kinase inhibitors
- Development of resistance to targeted therapies
- Immune-related adverse events
Interacting Drugs
BTK inhibitors (e.g., Ibrutinib)
SYK inhibitors
Associated Biomarkers
| Biomarker |
|---|
| LYN kinase expression/activity (in CLL) |
| BCR signaling activity |
| Mutational status of BCR pathway components |