B7 Proteins: CD80 (B7-1) and CD86 (B7-2) (B7)

CD80 (B7-1) and CD86 (B7-2) are type I transmembrane glycoproteins belonging to the immunoglobulin superfamily, expressed primarily on antigen-presenting cells (APCs). They provide costimulatory signals to T cells through interaction with CD28, leading to T cell activation. They also interact with CTLA-4, delivering inhibitory signals that regulate T cell responses. CD80 and CD86 play a crucial role in modulating immune responses and are targets for immunotherapy.

Other names

CD80B7-1CD86B7-2

CD80 and CD86 bind to CD28 on T cells to provide costimulatory signals, promoting T cell activation and proliferation. They also bind to CTLA-4, delivering inhibitory signals that dampen T cell responses.