Bacillus coagulans GBI-30, 6086 (BC30)

Bacillus coagulans GBI-30, 6086 is a spore-forming, lactic acid-producing probiotic bacterium with GRAS status, known for its resilience to stomach acid, heat processing, and gastrointestinal conditions, allowing it to germinate in the small intestine. It produces digestive enzymes such as alkaline proteases that enhance protein and carbohydrate breakdown, improving amino acid absorption and utilization, as demonstrated in in vitro gut models, animal studies, and human trials where it increased blood levels of key amino acids like leucine, isoleucine, and glutamine when co-administered with proteins. The strain modulates gut microbiota by promoting beneficial bacteria like Faecalibacterium prausnitzii, increasing anti-inflammatory cytokines such as IL-10, and reducing pro-inflammatory markers like IL-6 and TNF-alpha. It supports digestive health by alleviating symptoms of irritable bowel syndrome (IBS), including abdominal pain, bloating, and irregular bowel movements, and shows benefits in immune response, respiratory symptoms, and muscle recovery in various populations. With a draft genome of 3,458,655 bp and confirmed safety for chronic use including in infants, it is commercially incorporated into foods like yogurt, cheese, and supplements without altering metabolic homeostasis in healthy models.

Other names

Bacillus coagulans BC30GanedenBC30Ganeden BC 30