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Target intelligence / Profile preview
Bacterial 50S Ribosomal Subunit (23S rRNA) (50S Ribosomal Subunit)
- Target
- 50S Ribosomal Subunit
- Molecular classification
- Ribosomal RNA, RNA, Ribonucleoprotein
01
Overview
The bacterial 50S ribosomal subunit is the larger component of the prokaryotic 70S ribosome, essential for protein synthesis. It primarily consists of 23S and 5S rRNAs and about 31 distinct proteins. Its main function is to catalyze peptide bond formation during translation. The peptidyl transferase center within the 23S rRNA is a key target for antibiotics.
- Other names
- 50S subunitLarge ribosomal subunit23S rRNA
02
Mechanism of action
Inhibition of protein synthesis by binding to the 23S rRNA within the 50S ribosomal subunit, interfering with peptide bond formation or tRNA binding.
03
Biological functions
Peptide bond formationPolypeptide elongationTranslationProtein synthesis
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistanceOff-target effects of antibiotics
06
Interacting drugs
Macrolides
4 more in the full profile.
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