Molecular Classification
Protein, Polysaccharide, Cell Surface Component, Virulence Factor
Other Names
Adhesin, Bacterial Adherence Factor, Fimbrial Adhesin, Pili Adhesin
Disease Roles
InfectionBacterial pathogenesisTissue tropism

Bacterial Adhesin Overview

Bacterial adhesins are cell-surface components or appendages of bacteria that facilitate adhesion to other cells or surfaces, typically within a host organism. They play a crucial role in the initial stages of bacterial infection by enabling bacteria to colonize and persist in specific environments. Targeting bacterial adhesins is a promising strategy for preventing bacterial infections.

Mechanism of Action

Inhibition of bacterial adhesion to host cells, blocking colonization and preventing infection establishment.

Biological Functions

Cell adhesion
Host cell binding
Colonization
Biofilm formation
Immune evasion

Disease Associations

Infection
Bacterial pathogenesis
Tissue tropism
Inflammation

Safety Considerations

  • Potential for off-target effects on commensal bacteria
  • Development of resistance through adhesin mutation
  • Immune response to adhesin-based vaccines

Interacting Drugs

Fimbrolides
Adhesion inhibitors
Vaccines (targeting adhesins)
Antibodies (targeting adhesins)