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Bacterial Cell Membrane

Molecular classification
Membrane, Lipid Bilayer
01

Overview

The bacterial cell membrane is a phospholipid bilayer that encloses the cytoplasm of bacterial cells. It is responsible for regulating the transport of molecules into and out of the cell, generating energy through the electron transport chain, and synthesizing cell wall precursors. It is a major target for antibiotics due to its essential role in bacterial survival and its compositional differences from eukaryotic cell membranes. Examples of components are phosphatidylethanolamine, phosphatidylglycerol, and cardiolipin. The membrane also includes proteins that function as transporters, enzymes, and receptors. Some bacteria contain hopanoids which are sterol-like molecules.

Other names
Plasma Membrane (Bacterial)Cytoplasmic Membrane (Bacterial)
02

Mechanism of action

Disruption of membrane integrity/function

03

Biological functions

Selective barrierTransportEnergy generationBiosynthesisSignal transductionCell integrityPermeability
04

Disease associations

InfectionDrug resistance
05

Safety considerations

Off-target effects on mammalian cell membranesDevelopment of resistance
06

Interacting drugs

Daptomycin

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