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Target intelligence / Profile preview
Bacterial Cell Wall (Propionibacterium acnes)
- Molecular classification
- Cell Wall, Peptidoglycan, Teichoic acids
01
Overview
The bacterial cell wall of *Propionibacterium acnes* (*Cutibacterium acnes*) is a Gram-positive structure primarily composed of a thick peptidoglycan layer and teichoic acids. It provides essential functions including maintaining cellular shape, protecting against osmotic stress, filtering large molecules, contributing to biofilm formation, and playing roles in host-pathogen interactions. Due to its essential role in bacterial survival and its absence in eukaryotes, enzymes involved in peptidoglycan synthesis are important antibiotic targets.
- Other names
- Peptidoglycan (Propionibacterium acnes)Murein (Propionibacterium acnes)Cell wall of Cutibacterium acnes
02
Mechanism of action
Inhibition of peptidoglycan synthesis, leading to cell wall disruption and bacterial lysis.
03
Biological functions
Shape maintenanceProtection against osmotic lysisBarrier functionBiofilm formationAdhesion
04
Disease associations
Acne vulgarisDevice-related infectionsOpportunistic infections
05
Safety considerations
Antibiotic resistanceDisruption of normal skin flora
06
Interacting drugs
Beta-lactam antibiotics
2 more in the full profile.
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