Gosset Molecular Classification
Peptide, Cell Wall Component
Other Names
Pentaglycine bridge, Peptidoglycan interpeptide bridge, Glycine cross-link, Cell wall cross-linking peptide
Disease Roles
Bacterial Cell Wall Pentaglycyl Peptide Bridging Segment Overview
The bacterial cell wall pentaglycyl peptide bridging segment is a structural component found in the peptidoglycan layer of certain Gram-positive bacteria, notably *Staphylococcus aureus*. This segment, consisting of five glycine residues, connects peptide side chains attached to N-acetylmuramic acid (MurNAc) residues, providing strength and rigidity to the cell wall. It's a key target for antibiotics like lysostaphin and beta-lactams, and variations contribute to antibiotic resistance.
Mechanism of Action
Inhibition of cross-linking; cleavage of pentaglycine bonds.
Biological Functions
Cell wall integrity
Peptidoglycan cross-linking
Structural support
Resistance to osmotic lysis
Disease Associations
Bacterial infection
Antibiotic resistance
Safety Considerations
- Development of resistance
- Off-target effects of lysostaphin
Interacting Drugs
Lysostaphin