Bacterial Cell Wall Peptidoglycan Cross-Linking Enzyme (PBP)

Bacterial Cell Wall Peptidoglycan Cross-Linking Enzyme Overview

The bacterial cell wall peptidoglycan cross-linking enzyme is a critical catalyst in the final stages of bacterial cell wall biosynthesis. Its main function is to form peptide cross-links between glycan strands in the peptidoglycan layer, providing structural integrity and rigidity to the bacterial cell wall. This process is essential for maintaining cell shape and protecting bacteria from osmotic lysis. Key enzymes include transpeptidases (Penicillin-Binding Proteins, PBPs) and LD-transpeptidases, which are targets for β-lactam antibiotics. Variations or mutations can confer antibiotic resistance.

Mechanism of Action

Inhibition of peptidoglycan cross-linking, leading to weakened cell walls and bacterial lysis

Biological Functions

Safety Considerations

Interacting Drugs