Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Bacterial DNA Synthesis Enzyme (DNA)
- Target
- DNA
- Molecular classification
- Enzyme, Polymerase
01
Overview
The bacterial DNA synthesis enzyme, primarily DNA polymerase III (DNA pol III), is a crucial enzyme complex responsible for replicating the bacterial genome during cell division. It catalyzes the addition of deoxyribonucleotides to a growing DNA strand in the 5' to 3' direction, using a template strand for guidance. Other enzymes, like DNA polymerase I, play supporting roles in primer removal and DNA repair. Due to its essential role in bacterial survival and its structural differences from eukaryotic counterparts (e.g. gyrase), it is a key target for antibacterial drug development.
- Other names
- DNA Polymerase IIIDNA pol IIIDNA Replication Enzyme (Bacterial)
02
Mechanism of action
Inhibition of DNA synthesis by targeting DNA polymerase III or related enzymes (e.g., DNA gyrase)
03
Biological functions
DNA synthesisGenome duplicationCell divisionDNA replicationProofreading
04
Disease associations
Infection
05
Safety considerations
Off-target effects on eukaryotic DNA polymerases (though less likely with bacterial-specific targets)Development of antibiotic resistanceToxicity related to disruption of DNA synthesis
06
Interacting drugs
Quinolones
2 more in the full profile.
Beyond the preview
Go deeper on Bacterial DNA Synthesis Enzyme (DNA).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Bacterial DNA Synthesis Enzyme (DNA).