Gosset Molecular Classification
Enzyme, Hydrolase, Transferase, Oxidoreductase
Other Names
Bacterial proteins, Microbial enzymes
Disease Roles
Bacterial Enzymes Overview
Bacterial enzymes are proteins produced by bacteria that catalyze a wide range of biochemical reactions essential for bacterial survival, metabolism, and pathogenicity. They are crucial targets for antibacterial drug development. Examples include β-lactamases, penicillin-binding proteins (PBPs), and hydroxy-L-proline dehydratase (HypD).
Mechanism of Action
Lowering activation energy for biochemical reactions by stabilizing transition states through precise substrate binding at active sites. Inhibition of bacterial enzymes leads to halting growth or death of bacteria.
Biological Functions
Metabolic catalysis
Nutrient acquisition
Cell wall synthesis
Antibiotic resistance
Energy production
Pathogenicity
Breakdown of host tissues
Evasion of immune responses
Disease Associations
Infection
Antibiotic resistance
Clostridioides difficile infection
Safety Considerations
- Potential for off-target effects on human homologs
- Development of resistance mechanisms
Interacting Drugs
β-lactam antibiotics (penicillins, cephalosporins)
Macrolide antibiotics
Tetracyclines
Aminoglycosides