Bacterial fimbrin D-mannose adhesin ()

Bacterial fimbrin D-mannose adhesin Overview

FimH is a bacterial adhesin protein found at the tip of type 1 fimbriae (pili) in Gram-negative bacteria, most notably *Escherichia coli*. Its primary function is to mediate the attachment of bacteria to host cells by specifically binding to D-mannose residues on the surface glycoproteins of host tissues. This interaction is crucial for bacterial colonization and infection, particularly in urinary tract infections (UTIs). FimH exhibits "catch bond" behavior: its affinity for mannose increases when subjected to mechanical stress such as fluid shear, enhancing bacterial retention.

Mechanism of Action

Inhibition of mannose binding

Biological Functions

Safety Considerations