Bacterial glycocalyx ()

Bacterial glycocalyx Overview

The **bacterial glycocalyx** is a carbohydrate-rich extracellular layer that surrounds the outer surface of many bacteria. It is primarily composed of polysaccharides, glycoproteins, proteoglycans, and sometimes polypeptides. The structure can vary between a tightly bound form known as a **capsule** or a more loosely associated **slime layer**[2][4][6]. This layer serves several critical functions in bacterial physiology and pathogenesis: - It protects bacteria from desiccation, phagocytosis by immune cells, and attack by protozoans. - The glycocalyx enables bacteria to adhere strongly to surfaces—including host tissues—facilitating colonization and the formation of biofilms. - In pathogenic bacteria such as *Streptococcus pneumoniae*, the capsule form of the glycocalyx is essential for virulence because it helps evade host immune responses[4][5]. - The presence of a robust glycocalyx can impede antibiotic penetration, contributing significantly to chronic infection states due to enhanced resistance mechanisms within biofilms[3][5]. The composition varies among species but typically includes acidic mucopolysaccharides like hyaluronan or heparan sulfate in addition to various glycoproteins. While not itself an enzyme or receptor in the classical sense, the bacterial glycocalyx is considered an important therapeutic target due to its role in infection persistence and immune evasion. No universal abbreviation exists for "bacterial glycocalyx," though terms like "capsule" are used when referring specifically to its dense form. There are no standardized biomarkers for patient selection based solely on this structure; however, detection methods exist for identifying encapsulated strains during clinical diagnosis. Therapeutic challenges include overcoming the protective barrier function that limits drug access—making eradication especially difficult in established biofilms—and addressing variability between different bacterial species' glycocalyces[3][5].

Mechanism of Action

Disruption of glycocalyx integrity to enhance immune clearance or antibiotic penetration

Biological Functions

Safety Considerations

Interacting Drugs