Bacterial membrane (of pathogenic bacteria)

Pathogenic bacteria have cytoplasmic (plasma) membranes composed primarily of phospholipids and proteins, with other unique adaptations depending on the type (Gram-negative or Gram-positive)[2][4][5]. In Gram-negative bacteria, this includes a distinctive outer membrane containing lipopolysaccharide (LPS), which is a major virulence determinant and the source of endotoxin[3][4][5]. The bacterial membrane acts as a selective barrier, houses essential metabolic enzymes (e.g., for respiration), and is a functional target for several classes of antibiotics. Disruption of bacterial membranes is a proven therapeutic strategy, but targeting specificity and host toxicity remain challenges[2][3][5]. Targeting membrane structure or function is particularly relevant in combatting antibiotic-resistant pathogens, as membrane composition and permeability often underlie resistance mechanisms[4][5].

Other names

bacterial cell membranecytoplasmic membraneplasma membrane (context: pathogenic bacteria)

Disruption of membrane integrity, Increased membrane permeability, Destabilization of membrane potential or proton motive force