Bacterial Nitroreductase (NTR)

Bacterial Nitroreductase Overview

Bacterial nitroreductases are flavin-dependent oxidoreductase enzymes that catalyze the reduction of nitroaromatic and nitroheterocyclic compounds. They are involved in prodrug activation, converting inert compounds into active drugs, and can also contribute to antimicrobial resistance. NTRs operate via a ping-pong bi-bi redox mechanism using NADH/NADPH as electron donors. They are classified as Type I (oxygen-insensitive) or Type II (oxygen-sensitive). Their activity is exploited in gene-directed enzyme prodrug therapy (GDEPT) for cancer treatment.

Mechanism of Action

Reductive activation of nitro-containing prodrugs, releasing active metabolites or cytotoxic species.

Biological Functions

Safety Considerations

Interacting Drugs