Bacterial Penicillin-Binding Proteins (PBPs)

Bacterial Penicillin-Binding Proteins Overview

Penicillin-binding proteins (PBPs) are a diverse group of enzymes found in bacteria that play essential roles in the synthesis and maintenance of the bacterial cell wall. They catalyze transglycosylation and transpeptidation reactions in peptidoglycan biosynthesis. They are targets for β-lactam antibiotics. Resistance mechanisms, such as altered PBPs, can reduce antibiotic efficacy.

Mechanism of Action

β-lactam antibiotics covalently bind to the active site serine residue within PBPs' transpeptidase domains, blocking cross-linking activity, weakening the cell wall, and leading to bacterial lysis.

Biological Functions

Safety Considerations

Interacting Drugs