Target intelligence / Profile preview

Bacterial proteins (Cutibacterium acnes)

Molecular classification
Enzyme, Hydrolase, Glycoside hydrolase, Esterase, Lipase, Protease, Adhesin, ABC transporter, Other
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Overview

Bacterial proteins from Cutibacterium acnes (formerly Propionibacterium acnes) are a diverse set of molecules, including enzymes, adhesins, and other secreted factors, that contribute to the bacterium's role as both a commensal organism and an opportunistic pathogen. These proteins are implicated in acne vulgaris, implant-associated infections, and other inflammatory conditions. Certain secreted proteins contribute to host tissue breakdown and inflammatory responses, making them potential therapeutic targets. Variations in strain-specific secreted factors such as putative adhesins influence virulence properties.

Other names
Propionibacterium acnes proteinsCutibacterium acnes proteinsP. acnes secreted proteinsC. acnes secreted proteinsP. acnes virulence factorsC. acnes virulence factors
02

Mechanism of action

Antibiotic; inhibition of bacterial protein synthesis/cell wall synthesis/DNA replication

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Biological functions

Host tissue degradationInflammationBiofilm formationAdhesionMetabolismImmune activationOther
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Disease associations

Acne vulgarisChronic blepharitisEndophthalmitisProsthetic joint infectionImplant-associated infectionsOther
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Safety considerations

Antibiotic resistanceInflammatory responseBiofilm formationPotential for strain-specific virulence
06

Interacting drugs

Erythromycin

3 more in the full profile.

07

Biomarkers

Immunogenic bacterial proteins during infectionSpecific protein upregulation during planktonic growthSpecific protein upregulation during biofilm formation

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