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Bacterial Ribosome A-site RNA (Helix 44, 16S rRNA) (h44 16S rRNA)
- Target
- h44 16S rRNA
- Molecular classification
- RNA, Ribosomal RNA
01
Overview
The bacterial ribosome’s A-site RNA—specifically helix 44 within its universally conserved 16S rRNA—is central to accurate decoding during protein synthesis. It forms part of both functional centers for tRNA selection at the aminoacyl site and interfaces with key translational factors that regulate start codon recognition. Its unique structure makes it an attractive target for antibiotics that disrupt prokaryotic but not eukaryotic translation machinery.
- Other names
- Helix 4416S rRNA A-siteRibosomal A-site RNA
02
Mechanism of action
Inhibition of bacterial protein synthesis
03
Biological functions
mRNA decodingtRNA selectionTranslation initiationRibosome subunit interaction
04
Disease associations
Infection
05
Safety considerations
Potential for off-target effects of antibioticsDevelopment of antibiotic resistance
06
Interacting drugs
Tetracycline
2 more in the full profile.
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