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Target intelligence / Profile preview
Baculoviral IAP repeat-containing protein 7 (BIRC7) (BIRC7)
- Target
- BIRC7
- Molecular classification
- Inhibitor of apoptosis protein (IAP) family, Tumor-associated antigen (TAA), Peptide-MHC complex
01
Overview
- Other names
- LivinMelanoma inhibitor of apoptosis proteinML-IAPKidney inhibitor of apoptosis proteinKIAPBIRC7-derived peptide-MHC complexBIRC7-pMHC
02
Mechanism of action
Induction of antigen-specific cytotoxic T-lymphocyte (CTL) response through T-cell receptor recognition of BIRC7 peptides presented on MHC molecules, leading to selective lysis of BIRC7-expressing tumor cells (PubMed: 15150593).
03
Biological functions
Apoptosis inhibitionCaspase inhibitionCell survivalUbiquitin-protein transferase activityImmune recognition
04
Disease associations
CancerMelanomaLeukemiaColorectal cancerLung cancerBladder cancer
05
Safety considerations
On-target off-tumor toxicity in tissues with low BIRC7 expressionCytokine release syndrome (}
06
Interacting drugs
Investigational BIRC7 peptide vaccines
2 more in the full profile.
07
Biomarkers
BIRC7 protein expression (IHC)BIRC7 mRNA levelsHLA-A*02:01 statusAntigen-specific T-cell frequency
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