Molecular Classification
Receptor, Tumor Necrosis Factor Receptor Superfamily (TNFRSF)
Other Names
CD268, TNFRSF13C, BLyS receptor 3 (BR3), BROMIX, CVID4
Disease Roles
Autoimmune diseasesImmunodeficiencyCommon variable immunodeficiency (CVID)

BAFF Receptor Overview

The BAFF receptor (BAFF-R), also known as CD268 or TNFRSF13C, is a transmembrane receptor belonging to the TNF receptor superfamily. It specifically binds BAFF, a cytokine crucial for B cell survival and maturation. BAFF-R signaling, primarily through activation of NF-kB pathways, is essential for maintaining peripheral B cell homeostasis. Dysregulation of BAFF-R can contribute to autoimmune diseases and immunodeficiencies. Therapeutic targeting of BAFF-R signaling holds promise for treating these diseases and certain lymphomas.

Mechanism of Action

Blocking BAFF-R signaling

Biological Functions

Signal transduction
Immune response
B cell survival
B cell maturation
B cell homeostasis
NF-kB signaling

Disease Associations

Autoimmune diseases
Immunodeficiency
Common variable immunodeficiency (CVID)
Lymphoma
Chronic Kidney Disease

Safety Considerations

  • Potential for immunosuppression
  • Altered B cell numbers/function

Interacting Drugs

Small-molecule inhibitors of BAFF-R/BAFF interaction