BCAR1 scaffold protein, Cas family member (BCAR1 (also commonly referred to as p130Cas))

BCAR1 scaffold protein, Cas family member (p130Cas, BCAR1) is a multifunctional adaptor and scaffold protein crucial for integrating diverse intracellular signaling pathways. It plays a central role in processes such as cell adhesion, migration, proliferation, invasion, apoptosis, and survival. p130Cas functions mainly through phosphorylation-dependent interactions with multiple signaling partners, serving as a hub for receptor tyrosine kinase and integrin-mediated signal transduction, which influences the actin cytoskeleton and cellular responses to growth factors, extracellular matrix, and mechanical stress. It is a member of the Cas (Crk-associated substrate) protein family. Aberrant p130Cas expression or phosphorylation is strongly implicated in cancer progression, metastasis, and drug resistance, making it a potential diagnostic/prognostic marker in oncology, although its non-enzymatic and scaffold nature limits its direct therapeutic targeting[1][3][4][5][6][7].

Other names

p130CasCrk-associated substrate p130Breast cancer anti-estrogen resistance protein 1CASCASS1Crkas

Drugs targeting upstream kinases (such as Src or EGFR inhibitors) may affect p130Cas function by modulating its tyrosine phosphorylation and thus downstream signaling[1].