Bcl-2-associated transcription factor 1 (BCLAF1) (BCLAF1)

Bcl-2-associated transcription factor 1 (BCLAF1) is a multifunctional protein that serves as a transcriptional repressor and an interaction partner for pro-survival Bcl-2 family members like Bcl-xL [UniProt: Q9NYF8]. It plays a pivotal role in several essential cellular processes, including pre-mRNA splicing, the DNA damage response, and the regulation of apoptosis [PubMed: 28656233]. In various malignancies, such as lung and colorectal cancers, BCLAF1 is frequently overexpressed and contributes to tumor progression and resistance to therapy [PubMed: 30106620]. Consequently, BCLAF1 mRNA has emerged as a potential therapeutic target, with experimental approaches utilizing siRNAs or antisense oligonucleotides to reduce its expression and sensitize cancer cells to apoptosis [PubMed: 31435104]. Although no BCLAF1-targeted therapies are currently in clinical use, its involvement in key survival pathways and its interaction with the apoptotic machinery make it a promising candidate for future drug development.

Other names

BTFBcl-2-associated transcription factor 1Bcl2-associated transcription factor 1

Reduction of BCLAF1 protein levels through targeted mRNA degradation or translational inhibition, leading to the restoration of apoptotic pathways in cancer cells [PubMed: 31435104].