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Target intelligence / Profile preview
Beta 1,3 Glucan (β-1,3-glucan)
- Target
- β-1,3-glucan
- Molecular classification
- Polysaccharide, Dietary Fiber, Immunomodulator
01
Overview
Beta 1,3 glucan is a polysaccharide composed of D-glucose monomers linked primarily by β-1,3-glycosidic bonds. It is found in the cell walls of fungi, yeast, some bacteria, and plants. It acts as an immunomodulator by binding to receptors on immune cells, stimulating innate immune responses and enhancing immune surveillance against tumors. Its structure and branching patterns affect its solubility and biological activity.
- Other names
- Beta-1,3-D-Glucanβ-(1,3)-glucanβ-1,3 glucanBeta glucan
02
Mechanism of action
Binds to Dectin-1, CR3, and/or TLRs on immune cells, triggering downstream signaling pathways that activate the innate immune system, promote phagocytosis, and stimulate cytokine production.
03
Biological functions
Structural component of fungal and bacterial cell wallsImmune stimulationMacrophage activationDendritic cell activationNeutrophil activationAdjuvant
04
Disease associations
Cancer (immunotherapy)Infections (adjunct therapy)Inflammation (immunomodulation)
05
Safety considerations
Potential for excessive immune stimulationVariability in purity and composition depending on sourcePotential for allergic reactionsGastrointestinal side effects
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