Beta-1,3-N-acetylgalactosaminyltransferase 1 (B3GALNT1)

Beta-1,3-N-acetylgalactosaminyltransferase 1 (B3GALNT1) is an enzyme encoded by the B3GALNT1 gene in humans. It is a type II membrane-bound glycosyltransferase that catalyzes the transfer of N-acetylgalactosamine onto globotriaosylceramide, producing globoside (Gb4), which is an important glycolipid present on cell surfaces. B3GALNT1's activity defines the GLOB (P) blood group system, with key roles in blood group antigen synthesis. It is involved in glycosphingolipid and sphingolipid metabolism and contributes to processes such as embryonic development and cell surface structural diversity. There is emerging evidence linking B3GALNT1 to various blood group systems and possibly to metastasis regulation in cancers, but no approved therapeutic drugs currently target this enzyme directly[1][3][4][5][10].

Other names

Beta3Gal-T3Globoside synthaseB3GALANT1B3GALT3GalT3GLOBUDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferaseUDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3 (Globoside blood group)Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferaseBeta-1,3-galactosyltransferase 3P antigen synthaseBeta-1,3-GalNAc-T1Beta-1,3-GalTase 3Beta-3-Gx-T33-GalNAc-T1Brainiac1Gb4CerGLCT3P1P blood group globoside