Molecular Classification
GPCR, G protein-coupled receptor, Receptor, Class A/rhodopsin-like GPCR
Other Names
ADRB2, Beta2AR, Beta-2 adrenergic receptor
Disease Roles
AsthmaCOPDObesity

Beta adrenergic receptor beta2 subtype Overview

The beta-2 adrenergic receptor (β₂AR), also known as ADRB2, is a member of the G protein-coupled receptor (GPCR) superfamily. It primarily binds the endogenous catecholamines epinephrine (adrenaline) and norepinephrine. Upon activation, β₂AR stimulates adenylate cyclase via Gs proteins, leading to increased intracellular cyclic AMP (cAMP), which mediates various physiological responses such as smooth muscle relaxation and bronchodilation.

Mechanism of Action

Agonists bind to the receptor, activating Gs protein, increasing cAMP production, and activating protein kinase A (PKA), leading to downstream effects like smooth muscle relaxation.

Biological Functions

Signal transduction
Smooth muscle relaxation
Bronchodilation
Vasodilation
Glycogenolysis
Gluconeogenesis
Immune response modulation

Disease Associations

Asthma
COPD
Obesity
Type 2 diabetes
Respiratory disease

Safety Considerations

  • Desensitization with prolonged agonist exposure
  • Genetic polymorphisms affecting drug response
  • Clinical tolerance to chronic therapy with β₂ agonists

Interacting Drugs

Epinephrine
Norepinephrine
Albuterol
Salbutamol
Carazolol

Associated Biomarkers

Biomarker
ADRB2 polymorphisms