Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Beta adrenergic receptor beta2 subtype (BETA2)
- Target
- BETA2
- Molecular classification
- GPCR, G protein-coupled receptor, Receptor, Class A/rhodopsin-like GPCR
01
Overview
The beta-2 adrenergic receptor (β₂AR), also known as ADRB2, is a member of the G protein-coupled receptor (GPCR) superfamily. It primarily binds the endogenous catecholamines epinephrine (adrenaline) and norepinephrine. Upon activation, β₂AR stimulates adenylate cyclase via Gs proteins, leading to increased intracellular cyclic AMP (cAMP), which mediates various physiological responses such as smooth muscle relaxation and bronchodilation.
- Other names
- ADRB2Beta2ARBeta-2 adrenergic receptor
02
Mechanism of action
Agonists bind to the receptor, activating Gs protein, increasing cAMP production, and activating protein kinase A (PKA), leading to downstream effects like smooth muscle relaxation.
03
Biological functions
Signal transductionSmooth muscle relaxationBronchodilationVasodilationGlycogenolysisGluconeogenesisImmune response modulation
04
Disease associations
AsthmaCOPDObesityType 2 diabetesRespiratory disease
05
Safety considerations
Desensitization with prolonged agonist exposureGenetic polymorphisms affecting drug responseClinical tolerance to chronic therapy with β₂ agonists
06
Interacting drugs
Epinephrine
4 more in the full profile.
07
Biomarkers
ADRB2 polymorphisms
Beyond the preview
Go deeper on Beta adrenergic receptor beta2 subtype (BETA2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Beta adrenergic receptor beta2 subtype (BETA2).