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Target intelligence / Profile preview
Beta-globin gene (HBB)
- Target
- HBB
- Molecular classification
- Globin, Structural protein
01
Overview
The beta-globin gene (HBB) encodes the beta-globin protein, a critical subunit of hemoglobin, responsible for oxygen transport in red blood cells. Mutations in HBB cause significant diseases like sickle cell disease and beta thalassemia.
- Other names
- Hemoglobin subunit betaBeta globin
02
Biological functions
Oxygen transportHeme binding
03
Disease associations
Sickle cell diseaseBeta thalassemiaMethemoglobinemiaAnemia
04
Safety considerations
Genetic mutations leading to impaired oxygen transportTherapeutic gene editing risks (if applicable)
05
Biomarkers
HBB mutations (e.g., Glu6Val for sickle cell disease)Beta-globin protein levels
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