Molecular Classification
Globin, Structural protein
Other Names
Hemoglobin subunit beta, Beta globin
Disease Roles
Sickle cell diseaseBeta thalassemiaMethemoglobinemia

Beta-globin gene Overview

The beta-globin gene (HBB) encodes the beta-globin protein, a critical subunit of hemoglobin, responsible for oxygen transport in red blood cells. Mutations in HBB cause significant diseases like sickle cell disease and beta thalassemia.

Mechanism of Action

Biological Functions

Oxygen transport
Heme binding

Disease Associations

Sickle cell disease
Beta thalassemia
Methemoglobinemia
Anemia

Safety Considerations

  • Genetic mutations leading to impaired oxygen transport
  • Therapeutic gene editing risks (if applicable)

Associated Biomarkers

Biomarker
HBB mutations (e.g., Glu6Val for sickle cell disease)
Beta-globin protein levels