Beta-hydroxy beta-methylbutyric acid (HMB)

Beta-hydroxy beta-methylbutyric acid (HMB) is a naturally occurring small molecule produced in humans as a metabolite of the branched-chain amino acid L-leucine. It is found in small amounts in certain foods and is also produced endogenously in the liver and muscle cells. HMB has been widely studied for its potential to stimulate muscle protein synthesis, inhibit muscle protein breakdown, increase lean body mass, and support recovery after strenuous exercise or in situations of muscle wasting such as cancer, HIV/AIDS, or age-related sarcopenia. As a dietary supplement, HMB is used mainly by athletes and elderly individuals to help preserve muscle mass and strength. It is not associated with significant adverse effects when used as directed. Importantly, HMB is a metabolite and not a protein target, receptor, enzyme, or transporter[1][5][6][7].

Other names

beta-hydroxy beta-methylbutyrateβ-hydroxy β-methylbutyric acid3-hydroxy-3-methylbutanoic acid3-hydroxyisovaleric acidHMB

HMB exerts effects by stimulating protein synthesis and inhibiting protein breakdown in muscle tissue