Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Beta-lactamase (Ambler class A) (Class A Beta-Lactamase)
- Target
- Class A Beta-Lactamase
- Molecular classification
- Enzyme, Hydrolase, Beta-Lactamase, Ambler Class A Enzyme
01
Overview
Beta-lactamase (Ambler class A) enzymes are a family of serine-based enzymes produced by bacteria that confer resistance to beta-lactam antibiotics. They hydrolyze the beta-lactam ring of these antibiotics, rendering them inactive. Class A beta-lactamases include penicillinases, cephalosporinases, and extended-spectrum beta-lactamases (ESBLs) such as TEM, SHV, and CTX-M types, as well as carbapenemases like KPC. These enzymes are a major cause of antibiotic resistance in Gram-negative bacteria.
- Other names
- Ambler class A beta-lactamaseClass A beta-lactamasePenicillinaseCephalosporinaseExtended-spectrum beta-lactamase (ESBL)TEM-type ESBLSHV-type ESBLCTX-M-type ESBLKPC
02
Mechanism of action
Hydrolyzes the beta-lactam ring of beta-lactam antibiotics, preventing them from binding to penicillin-binding proteins (PBPs) and inhibiting bacterial cell wall synthesis.
03
Biological functions
Hydrolysis of beta-lactam ring in antibioticsAntibiotic resistanceDrug inactivation
04
Disease associations
InfectionAntibiotic resistanceTreatment failureHealthcare-associated infections
05
Safety considerations
Spread of antibiotic resistanceTreatment failureLimited therapeutic options for infections caused by beta-lactamase producing organismsNeed for combination therapies (e.g., beta-lactam/beta-lactamase inhibitor combinations)Emergence of carbapenem-resistant Enterobacterales (CRE)
06
Interacting drugs
Penicillins
4 more in the full profile.
07
Biomarkers
Detection of beta-lactamase genes (e.g., blaTEM, blaSHV, blaCTX-M, blaKPC) by PCR or other molecular methodsPhenotypic detection of beta-lactamase activity using chromogenic or iodometric assaysAntimicrobial susceptibility testing showing resistance to beta-lactam antibiotics
Beyond the preview
Go deeper on Beta-lactamase (Ambler class A) (Class A Beta-Lactamase).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Beta-lactamase (Ambler class A) (Class A Beta-Lactamase).