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Target intelligence / Profile preview
Beta-Lactamase (Ambler class C) (AmpC)
- Target
- AmpC
- Molecular classification
- Enzyme, Serine-based β-Lactamase
01
Overview
Beta-lactamases are enzymes produced by bacteria that confer resistance to beta-lactam antibiotics by hydrolyzing the beta-lactam ring. Ambler class C beta-lactamases (AmpC) are a major group and play a significant role in antibiotic resistance among Gram-negative bacteria. They hydrolyze penicillins, cephalosporins, and cephamycins but are poorly inhibited by clavulanate and tazobactam. Their expression can be chromosomal or plasmid-mediated and may be inducible, complicating treatment strategies.
- Other names
- AmpC beta-lactamaseCephalosporinaseCMY-type enzymesACT-typeDHA-type
02
Mechanism of action
Hydrolyzes the amide bond in the β-lactam ring of beta-lactam antibiotics, rendering them inactive.
03
Biological functions
Hydrolysis of beta-lactam antibioticsDrug resistance
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Treatment failures due to resistance developmentInducible expression leading to resistance during therapyPoor inhibition by common beta-lactamase inhibitors
06
Interacting drugs
Penicillins
7 more in the full profile.
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