Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Beta-lactamase (Ambler Class D) (Class D Beta-lactamase)
- Target
- Class D Beta-lactamase
- Molecular classification
- Enzyme, Hydrolase, Beta-lactamase
01
Overview
Beta-lactamases are enzymes produced by bacteria that confer resistance to beta-lactam antibiotics by hydrolyzing the beta-lactam ring of these drugs. Ambler Class D beta-lactamases, also known as oxacillinases, are serine-based enzymes that primarily hydrolyze penicillins and cloxacillin, but some members can also hydrolyze cephalosporins or carbapenems. They are a significant cause of antibiotic resistance, particularly in pathogens like Acinetobacter baumannii and Enterobacteriaceae.
- Other names
- OxacillinasesOXA-type beta-lactamases
02
Mechanism of action
Hydrolyzes the beta-lactam ring of beta-lactam antibiotics, inactivating their antibacterial properties.
03
Biological functions
Hydrolysis of beta-lactam antibioticsAntibiotic resistance
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Antibiotic resistanceTreatment failure in bacterial infectionsPoor inhibition by traditional beta-lactamase inhibitors
06
Interacting drugs
Penicillins
4 more in the full profile.
Beyond the preview
Go deeper on Beta-lactamase (Ambler Class D) (Class D Beta-lactamase).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Beta-lactamase (Ambler Class D) (Class D Beta-lactamase).