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Beta-lactamase (TEM-type) (None)
- Target
- None
- Molecular classification
- Enzyme, Hydrolase, Class A beta-lactamase
01
Overview
Beta-lactamase (TEM-type) refers to a family of enzymes, most notably TEM-1, that are among the most prevalent plasmid-encoded beta-lactamases found in Gram-negative bacteria. These enzymes confer resistance to beta-lactam antibiotics by hydrolyzing the beta-lactam ring, thereby deactivating the antibiotic's bactericidal properties. TEM-type beta-lactamases account for up to 90% of ampicillin resistance in E. coli and contribute significantly to resistance seen in Haemophilus influenzae, Neisseria gonorrhoeae, Klebsiella pneumoniae, among others. Their spread has led directly to increased prevalence of multidrug-resistant infections.
- Other names
- TEM-1TEM-type beta-lactamaseBeta-lactamase
02
Mechanism of action
Hydrolyzes the beta-lactam ring of beta-lactam antibiotics, rendering them inactive.
03
Biological functions
Hydrolysis of beta-lactam ringAntibiotic resistance
04
Disease associations
InfectionAntimicrobial resistance
05
Safety considerations
Development of antibiotic resistanceSpread of multidrug-resistant bacteria
06
Interacting drugs
Ampicillin
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