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Target intelligence / Profile preview
Beta-lactamase Class C Enzyme (AmpC)
- Target
- AmpC
- Molecular classification
- Enzyme, Serine hydrolase, Beta-lactamase
01
Overview
Beta-lactamase class C enzymes (AmpC beta-lactamases) are serine hydrolase enzymes produced by bacteria. They hydrolyze the beta-lactam ring of beta-lactam antibiotics, conferring resistance, particularly to cephalosporins. Commonly encoded chromosomally but can also be plasmid-borne. Expression can be inducible or constitutive. Not inhibited by most traditional beta-lactamase inhibitors. Play a significant role in antibiotic resistance among Gram-negative pathogens, limiting therapeutic options.
- Other names
- CephalosporinaseAmpC beta-lactamaseGroup 1 cephalosporinase
02
Mechanism of action
Hydrolyzes β-lactam antibiotics by forming an acyl-enzyme intermediate via their active-site serine residue, breaking open the β-lactam ring.
03
Biological functions
Hydrolyzes beta-lactam antibioticsConfers antibiotic resistance
04
Disease associations
InfectionAntibiotic resistance
05
Safety considerations
Emergence of antibiotic resistanceTreatment failures due to resistanceLimited treatment options for infections caused by AmpC-producing organismsInducibility and derepression of enzyme production complicating treatment
06
Interacting drugs
Penicillins
5 more in the full profile.
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