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Target intelligence / Profile preview
Beta-lactamase enzyme (Ambler class B) (MBL)
- Target
- MBL
- Molecular classification
- Enzyme, Hydrolase, Beta-lactamase, Metallo-beta-lactamase
01
Overview
Beta-lactamases are enzymes produced by bacteria that confer resistance to beta-lactam antibiotics by hydrolyzing the beta-lactam ring. Ambler class B comprises the metallo-beta-lactamases (MBLs), which require one or two zinc ions at their active site for catalytic activity. MBLs can hydrolyze a broad range of beta-lactams, including penicillins, cephalosporins, and carbapenems, but not monobactams. They are not inhibited by classic beta-lactamase inhibitors, posing a significant therapeutic challenge.
- Other names
- Metallo-beta-lactamaseAmbler class B beta-lactamase
02
Mechanism of action
Hydrolyzes the beta-lactam ring of beta-lactam antibiotics, rendering them inactive.
03
Biological functions
Antibiotic resistanceHydrolysis of beta-lactam antibiotics
04
Disease associations
InfectionAntimicrobial resistance
05
Safety considerations
Resistance to broad-spectrum beta-lactam antibioticsLimited treatment options for infections caused by MBL-producing bacteriaSpread of resistance genes via mobile genetic elementsLack of widely available effective inhibitors
06
Interacting drugs
Penicillins
3 more in the full profile.
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