Beta-lactamase TEM-1 (None)

Beta-lactamase TEM-1 Overview

Beta-lactamase TEM-1 is a class A beta-lactamase enzyme produced by Gram-negative bacteria. It is the most prevalent plasmid-encoded beta-lactamase and plays a major role in bacterial resistance to beta-lactam antibiotics, particularly penicillins and early-generation cephalosporins. It hydrolyzes the beta-lactam ring of susceptible antibiotics, rendering them ineffective. Its activity can be inhibited by mechanism-based inhibitors such as clavulanic acid; however, mutations have led to variants with extended-spectrum activity or inhibitor resistance.

Mechanism of Action

Ser70-mediated acylation/deacylation of beta-lactam antibiotics

Biological Functions

Safety Considerations

Interacting Drugs