Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Beta-N-acetylhexosaminidase (HEX)
- Target
- HEX
- Molecular classification
- Enzyme, Glycoside Hydrolase
01
Overview
Beta-N-acetylhexosaminidase is an exoglycosidase enzyme that catalyzes the hydrolysis of terminal, non-reducing β-N-acetylgalactosamine and β-N-acetylglucosamine residues from glycoconjugates. It plays a crucial role in the degradation of N-acetylated carbohydrates and glycoproteins by releasing N-acetylhexosamines. Deficiency in this enzyme leads to lysosomal storage disorders such as Tay-Sachs and Sandhoff diseases.
- Other names
- β-N-Acetyl-D-hexosaminideN-acetylhexosaminohydrolaseHexosaminidase AHexosaminidase BHexosaminidase Sβ-D-N-acetylhexosaminidaseβ-N-acetylglucosaminidase
02
Mechanism of action
Hydrolyzes terminal N-acetyl-D-glucosamine or galactosamine residues from glycoconjugates
03
Biological functions
Lysosomal degradationHydrolysis of glycoconjugatesChitin degradation
04
Disease associations
Tay-Sachs diseaseSandhoff diseaseLysosomal storage disorders
05
Safety considerations
Deficiency leads to severe neurodegenerative diseases
06
Biomarkers
Elevated levels in relapse during alcoholism treatmentDeficiency indicates lysosomal storage diseases
Beyond the preview
Go deeper on Beta-N-acetylhexosaminidase (HEX).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Beta-N-acetylhexosaminidase (HEX).