Gosset Molecular Classification
Enzyme, Aspartic acid peptidase, Transmembrane protein, Protease
Other Names
Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Membrane-associated aspartic protease 2, Memapsin-2, Aspartyl protease 2, ASP2
Disease Roles
Beta-secretase 1 Overview
Beta-secretase 1 (BACE1) is a transmembrane aspartic protease that initiates the production of amyloid-beta peptides by cleaving amyloid precursor protein (APP). This cleavage is a critical step in the pathogenesis of Alzheimer's disease. BACE1 also plays a role in myelination, particularly in peripheral nerves. It is considered a therapeutic target for Alzheimer's disease, with inhibitors aimed at reducing amyloid-beta production.
Mechanism of Action
Inhibition of BACE1 prevents the formation of amyloid-beta peptides.
Biological Functions
Amyloid precursor protein (APP) cleavage
Amyloid-beta peptide production
Myelination
Hydrolyzing peptide bonds
Disease Associations
Alzheimer's Disease
Osteoarthritis
Shoulder lesion
Safety Considerations
- Potential for cognitive side effects due to disruption of normal BACE1 function, such as myelination.
- Off-target effects due to BACE1's activity on other substrates.
Associated Biomarkers
| Biomarker |
|---|
| BACE1 levels in cerebrospinal fluid (CSF) |
| Amyloid-beta levels in CSF or brain imaging |