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Target intelligence / Profile preview
Beta-secretase 1 (BACE1)
- Target
- BACE1
- Molecular classification
- Enzyme, Aspartic acid peptidase, Transmembrane protein, Protease
01
Overview
Beta-secretase 1 (BACE1) is a transmembrane aspartic protease that initiates the production of amyloid-beta peptides by cleaving amyloid precursor protein (APP). This cleavage is a critical step in the pathogenesis of Alzheimer's disease. BACE1 also plays a role in myelination, particularly in peripheral nerves. It is considered a therapeutic target for Alzheimer's disease, with inhibitors aimed at reducing amyloid-beta production.
- Other names
- Beta-site amyloid precursor protein cleaving enzyme 1Beta-site APP cleaving enzyme 1Membrane-associated aspartic protease 2Memapsin-2Aspartyl protease 2ASP2
02
Mechanism of action
Inhibition of BACE1 prevents the formation of amyloid-beta peptides.
03
Biological functions
Amyloid precursor protein (APP) cleavageAmyloid-beta peptide productionMyelinationHydrolyzing peptide bonds
04
Disease associations
Alzheimer's DiseaseOsteoarthritisShoulder lesion
05
Safety considerations
Potential for cognitive side effects due to disruption of normal BACE1 function, such as myelination.Off-target effects due to BACE1's activity on other substrates.
06
Biomarkers
BACE1 levels in cerebrospinal fluid (CSF)Amyloid-beta levels in CSF or brain imaging
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