Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1)
- Target
- BACE1
- Molecular classification
- Enzyme, Pepsin family/aspartic proteases, Type I transmembrane protein
01
Overview
BACE1 is a transmembrane aspartyl protease responsible for the initial cleavage of amyloid precursor protein (APP) at the β-secretase site. This cleavage initiates the production of amyloid-beta peptides (Aβ), which are central to Alzheimer's disease pathology. BACE1 also plays a role in myelination and other neuronal functions, making it a challenging drug target due to potential off-target effects.
- Other names
- β-secretasebeta-site APP cleaving enzyme 1membrane-associated aspartic protease 2memapsin-2aspartyl protease 2ASP2
02
Mechanism of action
Inhibition of BACE1 enzymatic activity, preventing Aβ production
03
Biological functions
Cleavage of APPAβ peptide generationMyelination regulationSynaptic functionNeural developmentNeuregulin 1 cleavage
04
Disease associations
Alzheimer’s diseaseNeurodegenerative diseaseSchizophrenia (potential link)Cognitive deficits
05
Safety considerations
Off-target effects due to cleavage of other substratesPotential cognitive side effectsMyelination-related side effects
06
Interacting drugs
BACE1 inhibitors (small-molecule)
07
Biomarkers
Aβ40/42 levelsBACE1 activity levels
Beyond the preview
Go deeper on Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Beta-site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1).