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Bile Acid Sequestrant
- Molecular classification
- Anion exchange resin, Polymeric drug
01
Overview
Bile acid sequestrants are non-absorbable polymeric resins that bind to bile acids in the gastrointestinal tract, preventing their reabsorption and promoting their excretion. This leads to a reduction in LDL cholesterol levels. They are used in the treatment of hypercholesterolemia, bile acid malabsorption, and pruritus associated with cholestasis. Common examples include cholestyramine, colestipol, and colesevelam.
- Other names
- Bile acid resinsCholestyramineColestipolColesevelam
02
Mechanism of action
Binds bile acids in the gastrointestinal tract, preventing their reabsorption and promoting their excretion in feces. This forces the liver to convert more cholesterol into bile acids, lowering LDL cholesterol levels.
03
Biological functions
Bile acid bindingCholesterol reductionFecal excretion of bile acids
04
Disease associations
HypercholesterolemiaBile acid malabsorptionPruritus related to cholestasisType 2 diabetes mellitus
05
Safety considerations
ConstipationBloatingAbdominal pain/discomfortFlatulenceNausea/vomitingDiarrheaGallstone formationReduced absorption of other medicationsVitamin deficiencies (A, D, E, K)
06
Interacting drugs
Cholestyramine
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