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Bile Flow (Choleresis)

Molecular classification: Physiological process

Overview

Bile flow, or choleresis, is the secretion and movement of bile from hepatocytes in the liver through the biliary system into the duodenum. This process is essential for digestion and absorption of dietary fats and fat-soluble vitamins, as well as for excretion of waste products. It involves bile acid-dependent and bile acid-independent mechanisms regulated by transporters and nuclear receptors like FXR.

Other names: CholeresisBiliary secretion

Biological functions

Lipid digestion and absorptionElimination of cholesterol, bilirubin, drugs, and toxinsEnterohepatic circulationExcretion

Disease associations

CholestasisGallstonesLiver injury

Safety considerations

Impaired choleresis leads to cholestasis

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