Biogenesis of lysosomal organelles complex 1 subunit 6 (pallidin) (BLOC1S6)

Biogenesis of lysosomal organelles complex 1 subunit 6 (BLOC1S6, also known as pallidin or PLDN) is an integral structural subunit of the BLOC-1 complex, which is required for the normal biogenesis and function of lysosome-related organelles such as melanosomes, platelet dense granules, and acrosomes[1][2]. The protein regulates intracellular vesicular trafficking, particularly the sorting and delivery of membrane protein cargos to specialized organelles. BLOC1S6 interacts with other BLOC-1 subunits (including dysbindin, muted, and snapin) and with SNARE proteins such as Syntaxin 13 to mediate vesicle docking and fusion[1][2]. Mutations or dysregulation of BLOC1S6 cause Hermansky-Pudlak syndrome type 9 and are implicated in the pathology of granule formation defects and pigmentation disorders[1][2][6]. It is not a receptor, enzyme, or transporter, but rather a scaffolding protein involved in organizing vesicle transport machinery. Currently, there are no approved drugs targeting BLOC1S6 directly, but its involvement in key cellular processes means defects have significant consequences for cellular function[1][2][6].

Other names

PallidinPLDNHPS9PABLOS6BLOC-1 subunit pallidinPallid protein homologBLOC-1 subunit 6Syntaxin 13 binding protein 1 (Stx13bp1)

Not applicable. There are no drugs targeting BLOC1S6, so mechanisms of action for drug-target interaction are not defined.