Gosset Molecular Classification
PR-10 protein (Bet v 1), Profilin (Bet v 2), Polcalcin (Bet v 3/4), Isoflavone reductase (Bet v 6), Cyclophilin (Bet v 7), Glutathione-S-transferase (Bet v 8), Allergen
Other Names
Birch pollen allergens, Bet v 1, Bet v 2, Bet v 3, Bet v 4, Bet v 6, Bet v 7, Bet v 8
Disease Roles
Birch Group Pollen Allergens Overview
Birch group pollen allergens are a set of proteins found in the pollen of birch trees that are responsible for triggering allergic reactions in sensitized individuals. The primary allergenic protein is Bet v 1, a PR-10 protein. Other notable allergens include Bet v 2 (profilin) and Bet v 3/4 (polcalcins). These allergens exhibit significant cross-reactivity with other tree pollens and plant-derived foods, leading to conditions like oral allergy syndrome.
Mechanism of Action
Antihistamines block histamine receptors; corticosteroids reduce inflammation; allergen immunotherapy induces tolerance.
Biological Functions
Allergen-induced IgE production
Mast cell degranulation
Immune response
Cross-reactivity with plant proteins
Disease Associations
Allergic rhinitis
Allergic conjunctivitis
Asthma
Pollen-Food Allergy Syndrome (PFAS)
Oral Allergy Syndrome (OAS)
Safety Considerations
- Anaphylaxis (rare with pollen exposure, more relevant with immunotherapy)
- Cross-reactivity with food allergens
- Side effects of antihistamines and corticosteroids
Interacting Drugs
Antihistamines
Associated Biomarkers
| Biomarker |
|---|
| IgE antibodies to Bet v 1 |
| IgE antibodies to Bet v 2 |
| Skin prick test reactivity to birch pollen |
| Basophil activation test |